PDX Model DetailsJ000103634

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PDX Model Summary

Model Details

Model ID
J000103634
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
AJCC II / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Related Models

PDX models J000101173 and J000103634 originated from the same patient.

Publications citing this model

Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient

Sex
Female
Age (at time of tissue collection)
55
Race/Ethnicity
White / Hispanic
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample J000105168 from passage P1 has a TMB score of 0.81
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:J000105168 from passage P1     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P1 pathology consistent with sheets of high grade carcinoma. P2 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model J000103634 stained for H&E.

Patient tumor for PDX model J000103634 immunostained for ER. Staining was negative.

Patient tumor for PDX model J000103634 immunostained for ERBB2 (HER2). Staining was 1+ negative.

Patient tumor for PDX model J000103634 immunostained for Ki67. Staining was positive.

Patient tumor for PDX model J000103634 immunostained for PR. Staining was negative.

P1 tumor ID006 for PDX model J000103634 stained for H&E, shows sheets of high grade carcinoma.

P1 tumor ID006 for PDX model J000103634 immunostained for ER. Staining was negative.

P1 tumor ID006 for PDX model J000103634 immunostained for ERBB2 (HER2). Staining was 1+ negative.

P1 tumor ID006 for PDX model J000103634 immunostained for Ki67. Staining was positive.

P2 tumor F001 ID017 for PDX model J000103634 stained for H&E.

P1 tumor ID006 for PDX model J000103634 immunostained for PR. Staining was negative.

P2 tumor F001 ID017 for PDX model J000103634 stained for AR. Staining was negative.

P2 tumor F001 ID017 for PDX model J000103634 stained for AE1/AE3. Staining was positive.

P2 tumor F001 ID017 for PDX model J000103634 stained for CD45. Staining was negative.

P2 tumor F001 ID017 for PDX model J000103634 stained for ER. Staining was negative.

P2 tumor F001 ID017 for PDX model J000103634 stained for ERBB2(HER2). Staining was negative.

P2 tumor F001 ID017 for PDX model J000103634 stained for Ki67. Staining was positive.

P2 tumor F001 ID017 for PDX model J000103634 stained for PR. Staining was negative.

Dosing Studies

Circos Plots

no data