PDX Model DetailsJ000103917

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PDX Model Summary

Model Details
Model ID
J000103917
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
AJCC IA / Grade:III
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
66
Race/Ethnicity
White / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
no data

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample J000105382 from passage P0 has a TMB score of 8.89
Sample J000106043 from passage P1 has a TMB score of 8.89
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:J000105382 from passage P0     Score:MSI-S
Sample:J000106043 from passage P1     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0 pathology consistent with breats carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor ID001 for PDX model J000103917.
P0 tumor ID001 for PDX model J000103917 immunostained for ER. Staining was negative.

P0 tumor ID001 for PDX model J000103917 immunostained for CD45. Staining was negative.
P0 tumor ID001 for PDX model J000103917 immunostained for ERBB2 (HER2). Staining was negative.

P0 tumor ID001 for PDX model J000103917 immunostained for Ki67. Staining was negative.
P0 tumor ID001 for PDX model J000103917 immunostained for PR. Staining was negative.

P0 tumor ID001 for PDX model J000103917 immunostained for VIMENTIN. Staining was positive.
P0 tumor ID002 for PDX model J000103917 stained for H&E.

P1 tumor F001 P1 ID006 H&E ID002 for PDX model J000103917 stained for H&E.
P1 tumor F001 P1 ID006 H&E ID002 for PDX model J000103917 immunostained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data