PDX Model DetailsJ000104256

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PDX Model Summary

Model Details
Model ID
J000104256
Initial Diagnosis
Urinary bladder cancer
Final Diagnosis
Urinary bladder cancer
Stage/Grade
no data
Primary Site
Bladder
Sample Site
Bladder
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Male
Age (at time of tissue collection)
79
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
no data

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample J000105318 from passage P1 has a TMB score of 2.43
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:J000105318 from passage P1     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0 pathology consistent with urothelial carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis. P2 pathology done by Dr. Dorina Gui, University of California, Davis.

Patient tumor for PDX model J000104256 stained for H&E.
P0 tumor F001 for PDX model J000104256 stained for H&E.

P2 tumor F001 ID015 for PDX model J000104256 stained for H&E.
P2 tumor F001 ID015 for PDX model J000104256 stained for AE1AE3. Staining was positive.

P2 tumor F001 ID015 for PDX model J000104256 stained for CD45. Staining was negative.
P2 tumor F001 ID015 for PDX model J000104256 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data