PDX Model DetailsJ000104518

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PDX Model Summary

Model Details
Model ID
J000104518
Initial Diagnosis
Urinary bladder cancer
Final Diagnosis
Urinary bladder urothelial carcinoma
Stage/Grade
T2 / Grade:High
Primary Site
Bladder
Sample Site
Bladder
Tumor Type
no data

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Male
Age (at time of tissue collection)
86
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Unknown
Current Smoker/Former Smoker
no data

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample J000104907 from passage P0 has a TMB score of 41.99
Sample J000105345 from passage P1 has a TMB score of 41.99
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:J000104907 from passage P0     Score:MSI-S
Sample:J000105345 from passage P1     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
Papillary urothelial carcinoma, urinary bladder. P2 pathology consistent with urothelial carcinoma including the papillary growth pattern.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model J000104518 stained for H&E.
P2 tumor for PDX model J000104518 stained for H&E.

P2 tumor ID014 for PDX model J000104518 stained for AE1AE3. Staining was positive.
P2 tumor ID014 for PDX model J000104518 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots

 no data