PDX Model DetailsJ000106526

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PDX Model Summary

Model Details

Model ID (Previous ID)
J000106526 (BCM-3963)
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
/ Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Patient

Sex
Female
Age (at time of tissue collection)
32
Race/Ethnicity
White / Hispanic
Treatment Naïve?
Unknown
Current Smoker/Former Smoker
no data

Engraftment

Host Strain
no data
Sample Type
Biopsy (type unspecified)
Engraftment Site
Mammary Fat Pad

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Please Note: Expression data for this model is calculated as Log2(TPM+1)

Gene CNV

no CNV data

CNV Plots

no CNV plots

Tumor Mutation Burden

Sample J000116297 from passage P4 has a TMB score of 8.89
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:J000116297 from passage P4     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P4 pathology consistent with carcinoma. P5 pathology consistent with high grade carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P4 tumor F000 ID032 for PDX model J000106526 stained for H&E.

P4 tumor F000 ID032 for PDX model J000106526 stained for AE1AE3. Staining was positive.

P4 tumor F000 ID032 for PDX model J000106526 stained for AR. Staining was negative.

P4 tumor F000 ID032 for PDX model J000106526 stained for CD45. Staining was negative.

P4 tumor F000 ID032 for PDX model J000106526 stained for ER. Staining was negative.

P4 tumor F000 ID032 for PDX model J000106526 stained for ERBB2 (HER2). Staining was positive.

P4 tumor ID038 for PDX model J000106526 stained for ERBB2 (HER2). Staining was positive.

P4 tumor F000 ID032 for PDX model J000106526 stained for PR. Staining was negative.

P4 tumor F000 ID032 for PDX model J000106526 stained for Ki67. Staining was positive.

P5 tumor F000 ID30 for PDX model J000106526 stained for H&E.

P5 tumor F000 ID30 for PDX model J000106526 stained for AE1/AE3. Staining was positive.

P5 tumor F000 ID30 for PDX model J000106526 stained for AR. Staining was negative.

P5 tumor F000 ID30 for PDX model J000106526 stained for CD45. Staining was negative.

P5 tumor F000 ID30 for PDX model J000106526 stained for ER. Staining was negative.

P5 tumor F000 ID30 for PDX model J000106526 stained for ERBB2 (HER2). Staining was positive.

P5 tumor F000 ID30 for PDX model J000106526 stained for Ki67. Staining was positive.

P5 tumor F000 ID30 for PDX model J000106526 stained for PR. Staining was negative.

Dosing Studies

no data

Circos Plots

no data