PDX Model DetailsJ000106527

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PDX Model Summary

Model Details
Model ID (Previous ID)
J000106527 (BCM-3469)
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
T4 / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Patient
Sex
Female
Age (at time of tissue collection)
36
Race/Ethnicity
White / Hispanic
Treatment Naïve?
No
Current Smoker/Former Smoker
no data

Engraftment
Host Strain
no data
Sample Type
Surgical resection (fragment)
Engraftment Site
Mammary Fat Pad

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Please Note: Expression data for this model is calculated as Log2(TPM+1)

Gene CNV

no CNV data

CNV Plots

no CNV plots

Tumor Mutation Burden

 no data

Microsatellite Instability

 no data

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P3 pathology consistent with breast invasive ductal carcinoma, high grade.
Pathologist:
Dr. Dorina Gui, University of California, Davis.

P3 tumor F000 ID1393 for PDX model J000106527 stained for H&E.
P3 tumor F000 ID1393 for PDX model J000106527 stained for AE1AE3. Staining was positive.

P3 tumor F000 ID1393 for PDX model J000106527 stained for AR. Staining was negative.
P3 tumor F000 ID1393 for PDX model J000106527 stained for CD45. Staining was negative.

P3 tumor F000 ID1393 for PDX model J000106527 stained for ER. Staining was negative.
P3 tumor F000 ID1393 for PDX model J000106527 stained for ERBB2 (HER2). Staining was negative.

P3 tumor F000 ID1393 for PDX model J000106527 stained for Ki67. Staining was positive.
P3 tumor F000 ID1393 for PDX model J000106527 stained for PR. Staining was negative.

Dosing Studies

 no data

Circos Plots

 no data