PDX Model DetailsJ000106535

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PDX Model Summary
Model Details	Model ID (Previous ID) J000106535 (BCM-5097) Initial Diagnosis Invasive ductal carcinoma Final Diagnosis Invasive ductal carcinoma Stage/Grade AJCC IV / Grade:3 Primary Site Breast Sample Site Breast Tumor Type Primary Malignancy
Patient	Sex Female Age (at time of tissue collection) 40 Race/Ethnicity White / Not Reported Treatment Naïve? No Current Smoker/Former Smoker no data
Engraftment	Host Strain no data Sample Type Biopsy (type unspecified) Engraftment Site Right Flank

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: RNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details. Please Note: Expression data for this model is calculated as Log2(TPM+1)
Gene CNV	no CNV data
CNV Plots	no CNV plots
Tumor Mutation Burden	Sample J000115770 from passage P4 has a TMB score of 4.04 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:J000115770 from passage P4 Score:MSI-S
Gene Fusion	no data

Model Characterization

Histology

Summary:
P5 pathology consistent with poorly differentiated Carcinoma. The hormone receptor status for PDX model J000106535 is ER+/PR-/HER2-. Note that the clinical information provided to JAX reports that the patient is ER+/PR+/HER2-.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P5 tumor F000 ID027 for PDX model J000106535 stained for H&E.	P5 tumor F000 ID027 for PDX model J000106535 stained for AE1AE3. Staining was positive.
P5 tumor F000 ID027 for PDX model J000106535 stained for AR. Staining was positive.	P5 tumor F000 ID027 for PDX model J000106535 stained for CD45. Staining was negative
P5 tumor F000 ID027 for PDX model J000106535 stained for ER. Staining was positive	P5 tumor F000 ID027 for PDX model J000106535 stained for ERBB2 (HER2). Staining was negative.
P5 tumor F000 ID027 for PDX model J000106535 stained for PR. Staining was negative.	P5 tumor F000 ID027 for PDX model J000106535 stained for Ki67. Staining was positive.