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Last Database Update
2020-02-16
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:J000106560 Previous ID:PS4050
Primary Site:Skin Initial Diagnosis:melanoma Final Diagnosis:melanoma
Tumor Site:Skin Tumor Type:Primary Malignancy Stage / Grade:IV /
Patient
Sex:Male Age:79 Race / Ethnicity:White / Not Hispanic or Latino
Treatment Naive:Yes
Engraftment Host
Strain: Implantation Site:Right Flank Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample PS4050 has a TMB score of 6.46
 TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Microsatellite Instability Help
Sample:PS4050     Score:MSI-S
Variant Summary Help

Gene Expression Help Platforms:stRNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
P11 pathology is consistent with Melanoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

P11 tumor ID05 for PDX model J000106560 stained for AE1AE3. Staining was negative.
P11 tumor ID05 for PDX model J000106560 stained for S100. Staining was positive.
Dosing Studies: