PDX Model DetailsJ000106560

PDX Model Summary
Model Details	Model ID (Previous ID) J000106560 (PS4050) Initial Diagnosis Melanoma Final Diagnosis Melanoma Stage/Grade IV / Primary Site Skin Sample Site Skin Tumor Type Primary Malignancy
Publications citing this model	Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586. 10.7717/peerj.6586
Patient	Sex Male Age (at time of tissue collection) 79 Race/Ethnicity White / Not Hispanic or Latino Treatment Naïve? Yes Current Smoker/Former Smoker Unknown / Unknown
Engraftment	Host Strain no data Sample Type Surgical resection (fragment) Engraftment Site Right Flank

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: stRNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample PS4050 has a TMB score of 5.66 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:PS4050 Score:MSI-S
Gene Fusion	no data

Model Characterization

Summary:
P11 pathology is consistent with Melanoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

P11 tumor ID05 for PDX model J000106560 stained for AE1AE3. Staining was negative.

P11 tumor ID05 for PDX model J000106560 stained for S100. Staining was positive.

no data