PDX Model DetailsJ000106560

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Model Details

Model ID (Previous ID)
J000106560 (PS4050)
Primary Site
Skin
Tumor Site
Skin
Tumor Type
Primary Malignancy
Initial Diagnosis
melanoma
Final Diagnosis
melanoma
Stage/Grade
IV /

Patient

Sex
Male
Age
79
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve
Yes

Engraftment Host

Implantation Site
Right Flank
Sample Type
Surgical resection (fragment)

Tumor Mutation Burden

Sample
Sample PS4050 has a TMB score of 5.66
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:PS4050     Score:MSI-S

Variant Summary

Gene Expression

Platforms: stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
P11 pathology is consistent with Melanoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

P11 tumor ID05 for PDX model J000106560 stained for AE1AE3. Staining was negative.

P11 tumor ID05 for PDX model J000106560 stained for S100. Staining was positive.

Dosing Studies