Mouse Tumor Biology Database (MTB)
MTB Home   Help
Search Forms
Tumor
Strain
Genetics
Pathology Images
Reference
Advanced
Search MTB Using Human Genes
Gene Expression Data Sets
Additional Resources
new PDX Like Me
PDX Finder
PDX Model Search
Faceted Tumor Search
Dynamic Tumor Frequency Grid
Other Cancer Websites
Immunohistochemistry
Lymphoma Pathology
Mouse Genome Informatics
The Jackson Laboratory
Citing These Resources
Warranty Disclaimer
& Copyright Notice
Send Questions and
Comments to User Support.
Last Database Update
2020-03-29
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:J000106560 Previous ID:PS4050
Primary Site:Skin Initial Diagnosis:melanoma Final Diagnosis:melanoma
Tumor Site:Skin Tumor Type:Primary Malignancy Stage / Grade:IV /
Patient
Sex:Male Age:79 Race / Ethnicity:White / Not Hispanic or Latino
Treatment Naive:Yes
Engraftment Host
Strain: Implantation Site:Right Flank Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample PS4050 has a TMB score of 6.46
 TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Microsatellite Instability Help
Sample:PS4050     Score:MSI-S
Variant Summary Help

Gene Expression Help Platforms:stRNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
P11 pathology is consistent with Melanoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

P11 tumor ID05 for PDX model J000106560 stained for AE1AE3. Staining was negative.
P11 tumor ID05 for PDX model J000106560 stained for S100. Staining was positive.
Dosing Studies: