PDX Model DetailsJ000106560

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PDX Model Summary

Model Details

Model ID (Previous ID)
J000106560 (PS4050)
Initial Diagnosis
melanoma
Final Diagnosis
melanoma
Stage/Grade
IV /
Primary Site
Skin
Sample Site
Skin
Tumor Type
Primary Malignancy

Patient

Sex
Male
Age (at time of tissue collection)
79
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
no data
Sample Type
Surgical resection (fragment)
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample
Sample PS4050 has a TMB score of 5.66
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:PS4050     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P11 pathology is consistent with Melanoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

P11 tumor ID05 for PDX model J000106560 stained for AE1AE3. Staining was negative.

P11 tumor ID05 for PDX model J000106560 stained for S100. Staining was positive.

Dosing Studies

Circos Plots

no data