PDX Model DetailsTM00015

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00015 (BL0269F)
Initial Diagnosis
Carcinoma: Urothelial carcinoma
Final Diagnosis
Bladder urothelial papillary carcinoma
Stage/Grade
AJCC III / Grade:high
Primary Site
Bladder
Sample Site
Bladder
Tumor Type
Primary Malignancy

Publications citing this model

 Pan, C; et al. Development and Characterization of Bladder Cancer Patient-Derived Xenografts for Molecularly Guided Targeted Therapy. PLoS One 2015;10(8), p1-22. doi:10.1371/journal

Patient
Sex
Male
Age (at time of tissue collection)
58
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / No

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hg10st

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

 no data

Microsatellite Instability

 no data

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P1 pathology consistent with urothelial papillary carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00015. High grade urothelial carcinoma invading bladder wall.
P1 tumor #404-009 for PDX model TM00015. High grade urothelial carcinoma.

P1 tumor #404-009 for PDX model TM00015. Negative vimentin staining for tumor cells. Scattered positive staining cells (lymphocytes).
P1 tumor #404-009 for PDX model TM00015. Positive staining for Ki67 indicating tumor cells of human origin.

Dosing Studies

 no data

Circos Plots

Circos plot for P0 tumor #404