PDX Model DetailsTM00020

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00020 (BL0382F)
Initial Diagnosis
Carcinoma: Urothelial carcinoma
Final Diagnosis
Bladder transitional cell carcinoma
Stage/Grade
AJCC III / Grade:high
Primary Site
Bladder
Sample Site
Bladder
Tumor Type
Primary Malignancy

Publications citing this model

 Long, Q; et al. Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model. Nanomedicine 2018 Apr;14(3):789-799.  10.1016/j.nano.2017.12.014
Pan, C; et al. Development and Characterization of Bladder Cancer Patient-Derived Xenografts for Molecularly Guided Targeted Therapy. PLoS One 2015;10(8), p1-22. doi:10.1371/journal

Patient
Sex
Female
Age (at time of tissue collection)
82
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / No

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hg10st

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

 no data

Microsatellite Instability

 no data

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0 pathology consistent with bladder transitional cell carcinoma. P3 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00020. Nests of high grade urothelial carcinoma invading bladder muscle wall.
P0 tumor #1233 for PDX model TM00020. Sheets of high grade urothelial carcinoma cells.

P0 tumor #1235 for PDX model TM00020. Negative staining of tumor cells for vimentin. Scattered positive cells (lymphocytes).
P0 tumor #1235 for PDX model TM00020. Positive staining for Ki67 indicating tumor cells of human origin.

P3 tumor F1232 ID016 for PDX model TM00020 stained for H&E.
P3 tumor F1232 ID016 for PDX model TM00020 stained for AE1AE3. Staining was positive.

P3 tumor F1232 ID016 for PDX model TM00020 stained for CD45. Staining was negative.
P3 tumor F1232 ID016 for PDX model TM00020 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

Circos plot for P0 tumor #1232 for TM00020
Circos plot for P1 tumor # 0001 from PDX model TM00020