PDX Model DetailsTM00024

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00024 (BL0440F)
Initial Diagnosis
Carcinoma: Urothelial carcinoma
Final Diagnosis
bladder transitional cell carcinoma
Stage/Grade
AJCC IV / Grade:high
Primary Site
Bladder
Sample Site
Bladder
Tumor Type
Primary Malignancy

Publications citing this model

Pan, C; et al. Development and Characterization of Bladder Cancer Patient-Derived Xenografts for Molecularly Guided Targeted Therapy. PLoS One 2015;10(8), p1-22. doi:10.1371/journal

Patient

Sex
Male
Age (at time of tissue collection)
71
Race/Ethnicity
Black / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / Yes

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

no data

Microsatellite Instability

no data

Gene Fusion

no data

Model Characterization

Histology


Patient tumor for PDX model TM00024.

Patient tumor for PDX model TM00024; Vimentin

P1 tumor #1666 for PDX model TM00024.

P1 tumor #1666 for PDX model TM00024; Vimentin

Dosing Studies

Circos Plots


Circos plot