PDX Model Details

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PDX Model Details

Model Details


Model ID:	TM00090	Previous ID:	BR0744F
Primary Site:	Breast	Initial Diagnosis:	breast metaplastic carcinoma	Final Diagnosis:	breast metaplastic carcinoma
Tumor Site:	Breast	Tumor Type:	Primary Malignancy	Stage / Grade:	AJCC IV / Grade:3

Patient

Sex:	Female	Age:	43	Race / Ethnicity:	White / Not Hispanic or Latino
Treatment Naive:	Yes

Engraftment Host

Strain:

NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ
(aka NSG or NOD Scid gamma)

Implantation Site:

Sample Type:

Surgical resection (fragment)

Tumor Mutation Burden

Sample from passage P0 has a TMB score of 8.08

TMB Range:0.81-305.22 (across all JAX PDX models)
TMB > 22 is considered high.

Microsatellite Instability

Sample:BR0744F098P0 Score:MSI-S

Variant Summary

Gene Expression

Platforms:RNA_Seq, hg10st, stRNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology:

Summary:

Moderate concordance of tumor morphologic features between patient tumor and P0 tumor. P2 is consistent with high grade breast carcinoma.

Pathologist:

Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00090. Sheets of epithelial cells in a pseudoglandular pattern with abundant bluish mucin in the intercellular spaces.	P0 tumor #098 for PDX model TM00090. Sheets of epithelial cells in with abundant bluish mucin in the intercellular spaces.
P0 tumor #098 for PDX model TM00090; IHC for PR	P0 tumor #098 for PDX model TM00090; IHC for ER
P2 tumor F098 ID0111 for PDX model TM00090 stained for H&E.

Circos Plots:

Circos Plot for P0 tumor #097 from PDX Model TM00090 (aka, BR0744F)

Circos plot for P0 tumor #098 from TM00090 (aka, BR0744F)

Dosing Studies: