PDX Model DetailsTM00090

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00090 (BR0744F)
Initial Diagnosis
breast metaplastic carcinoma
Final Diagnosis
breast metaplastic carcinoma
Stage/Grade
AJCC IV / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Patient

Sex
Female
Age (at time of tissue collection)
43
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / No

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hg10st, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 8.89
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:BR0744F098P0     Score:MSI-S

Gene Fusion

Fusion Genes
Sample BR0744F098P0 has fusion gene RAD51AP1 - DYRK4

Model Characterization

Histology

Summary:
P0 pathology consistent with metaplastic breast carcinoma. P2 is consistent with high grade breast carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00090. Sheets of epithelial cells in a pseudoglandular pattern with abundant bluish mucin in the intercellular spaces.

P0 tumor #098 for PDX model TM00090. Sheets of epithelial cells in with abundant bluish mucin in the intercellular spaces.

P0 tumor #098 for PDX model TM00090; IHC for PR

P0 tumor #098 for PDX model TM00090; IHC for ER

P2 tumor F098 ID0111 for PDX model TM00090 stained for H&E.

Dosing Studies

Circos Plots


Circos Plot for P0 tumor #097 from PDX Model TM00090 (aka, BR0744F)

Circos plot for P0 tumor #098 from TM00090 (aka, BR0744F)