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Last Database Update
2019-09-15
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00096 Previous ID:BR0851F
Primary Site:Breast Initial Diagnosis:invasive ductal carcinoma Final Diagnosis:invasive ductal carcinoma
Tumor Site:Lung Tumor Type:Metastatic Stage / Grade:AJCC IIA / Grade:3
Patient
Sex:Female Age:52 Race / Ethnicity:White / Hispanic
Treatment Naive:No
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample from passage P0 has a TMB score of 8.89
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Variant Summary Help

Gene Expression Help Platforms:RNA_Seq, hg10st
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
P2 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor #002 for PDX model TM00096.

P0 tumor #003 for PDX model TM00096.

P0 tumor #002 for PDX model TM00096; PR marker (negative)

P0 tumor #003 for PDX model TM00096; PR marker (negative)

P0 tumor #002 for PDX model TM00096; ER marker (negative)

P0 tumor #003 for PDX model TM00096; ER marker (negative)

P0 tumor #002 for PDX model TM00096; HER2 (ERBB2) marker (negative)

P0 tumor #003 for PDX model TM00096 ; HER2 (ERBB2) marker (negative)

P2 tumor F002 ID014 for PDX model TM00096 stained for H&E.

P2 tumor F002 ID014 for PDX model TM00096 stained for AE1AE3. Staining was positive.

P2 tumor F002 ID014 for PDX model TM00096 stained for Ki67. Staining was positive.

P2 tumor F002 ID014 for PDX model TM00096 stained for AR. Staining was negative.
Circos Plots:

Circos plot for P0 tumor #002 from PDX model TM00096 (aka, BR0851)

Circos plot for P0 tumor #004 from PDX model TM00096 (aka, BR0851)
Dosing Studies: