PDX Model DetailsTM00096

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Model Details

Model ID (Previous ID)
TM00096 (BR0851F)
Primary Site
Breast
Tumor Site
Lung
Tumor Type
Metastatic
Initial Diagnosis
invasive ductal carcinoma
Final Diagnosis
invasive ductal carcinoma
Stage/Grade
AJCC IIA / Grade:3

Patient

Sex
Female
Age
52
Race/Ethnicity
White / Hispanic
Treatment Naïve
No

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 8.89
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:BR0851F004P0     Score:MSI-S

Variant Summary

Gene Expression

Platforms: RNA_Seq, hg10st

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
P2 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor #002 for PDX model TM00096.

P0 tumor #003 for PDX model TM00096.

P0 tumor #002 for PDX model TM00096; PR marker (negative)

P0 tumor #003 for PDX model TM00096; PR marker (negative)

P0 tumor #002 for PDX model TM00096; ER marker (negative)

P0 tumor #003 for PDX model TM00096; ER marker (negative)

P0 tumor #002 for PDX model TM00096; HER2 (ERBB2) marker (negative)

P0 tumor #003 for PDX model TM00096 ; HER2 (ERBB2) marker (negative)

P2 tumor F002 ID014 for PDX model TM00096 stained for H&E.

P2 tumor F002 ID014 for PDX model TM00096 stained for AE1AE3. Staining was positive.

P2 tumor F002 ID014 for PDX model TM00096 stained for Ki67. Staining was positive.

P2 tumor F002 ID014 for PDX model TM00096 stained for AR. Staining was negative.
Circos Plots:

Circos plot for P0 tumor #002 from PDX model TM00096 (aka, BR0851)

Circos plot for P0 tumor #004 from PDX model TM00096 (aka, BR0851)

Dosing Studies