PDX Model DetailsTM00098

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Model Details

Model ID (Previous ID)
TM00098 (BR1126F)
Primary Site
Breast
Tumor Site
Breast
Tumor Type
Primary Malignancy
Initial Diagnosis
invasive ductal carcinoma
Final Diagnosis
invasive ductal carcinoma
Stage/Grade
AJCC IA / Grade:3

Patient

Sex
Female
Age
64
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve
Yes

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 12.92
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:BR1126F030P0     Score:MSI-S

Variant Summary

Gene Expression

Platforms: RNA_Seq, hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
P1 is AE1/AE3 positive,AR, ER, PR, ERBB2 (Her2) negative. P0, P1 pathology consistent with high grade breast carcinoma. P2 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F028 for PDX model TM00098 stained for H&E.

P1 tumor F030 ID362 for PDX model TM00098 stained for H&E.

P1 tumor F030 ID362 for PDX model TM00098 stained for AE1AE3. Staining was positive.

P1 tumor F030 ID362 for PDX model TM00098 stained for AR. Staining was negative.

P1 tumor F030 ID362 for PDX model TM00098 stained for ER. Staining was negative.

P1 tumor F030 ID362 for PDX model TM00098 stained for ERBB2 (HER2). Staining was negative.

P1 tumor F030 ID362 for PDX model TM00098 stained for PR. Staining was negative.

P2 tumor F030 ID014 for PDX model TM00098 stained for H&E.

P2 tumor F030 ID014 for PDX model TM00098 stained for AE1AE3. Staining was positive.

P2 tumor F030 ID014 for PDX model TM00098 stained for Ki67. Staining was positive.

P2 tumor F030 ID014 for PDX model TM00098 stained for CD45. Staining was negative.

Dosing Studies