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Last Database Update
2019-09-15
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00098 Previous ID:BR1126F
Primary Site:Breast Initial Diagnosis:invasive ductal carcinoma Final Diagnosis:invasive ductal carcinoma
Tumor Site:Breast Tumor Type:Primary Malignancy Stage / Grade:AJCC IA / Grade:3
Patient
Sex:Female Age:64 Race / Ethnicity:White / Not Hispanic or Latino
Treatment Naive:Yes
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample from passage P0 has a TMB score of 12.12
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Variant Summary Help

Gene Expression Help Platforms:RNA_Seq, hu133, stRNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
P1 is AE1/AE3 positive,AR, ER, PR, ERBB2 (Her2) negative. High grade breast carcinoma, fidelity to P1.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F028 for PDX model TM00098 stained for H&E.

P1 tumor F030 ID362 for PDX model TM00098 stained for H&E.

P1 tumor F030 ID362 for PDX model TM00098 stained for AE1AE3. Staining was positive.

P1 tumor F030 ID362 for PDX model TM00098 stained for AR. Staining was negative.

P1 tumor F030 ID362 for PDX model TM00098 stained for ER. Staining was negative.

P1 tumor F030 ID362 for PDX model TM00098 stained for ERBB2 (HER2). Staining was negative.

P1 tumor F030 ID362 for PDX model TM00098 stained for PR. Staining was negative.

P2 tumor F030 ID014 for PDX model TM00098 stained for H&E.

P2 tumor F030 ID014 for PDX model TM00098 stained for AE1AE3. Staining was positive.

P2 tumor F030 ID014 for PDX model TM00098 stained for Ki67. Staining was positive.

P2 tumor F030 ID014 for PDX model TM00098 stained for CD45. Staining was negative.
Dosing Studies: