PDX Model Details

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PDX Model Details

Model Details


Model ID:	TM00099	Previous ID:	BR1367F
Primary Site:	Breast	Initial Diagnosis:	invasive ductal carcinoma	Final Diagnosis:	invasive ductal carcinoma
Tumor Site:	Breast	Tumor Type:	Primary Malignancy	Stage / Grade:	AJCC IIA / Grade:3

Patient

Sex:	Female	Age:	44	Race / Ethnicity:	Asian or Pacific Islander / Not Reported
Treatment Naive:	No

Engraftment Host

Strain:

NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ
(aka NSG or NOD Scid gamma)

Implantation Site:

Sample Type:

Surgical resection (fragment)

Tumor Mutation Burden

Sample from passage P0 has a TMB score of 3.23
Sample from passage P6 has a TMB score of 5.66

TMB Range:0.81-305.22 (across all JAX PDX models)
TMB > 22 is considered high.

Microsatellite Instability

Sample:BR1367F003P6 Score:MSI-S
Sample:BR1367F033P0 Score:MSI-S

Variant Summary

Gene Expression

Platforms:RNA_Seq, hg10st, stRNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology:

Patient tumor for PDX model TM00099.	Patient tumor for PDX model TM00099; PR marker (negative)
Patient tumor for PDX model TM00099; ER marker (negative)	P0 tumor #033 for PDX model TM00099.
P0 tumor #033 for PDX model TM00099; PR marker (negative)	P0 tumor #033 for PDX model TM00099; ER marker (negative)
P0 tumor #033 for PDX model TM00099; HER2 (ERBB2) marker (negative)

Circos Plots:

Circos plot for P0 tumor #033 from PDX model TM00099

Dosing Studies: