PDX Model DetailsTM00112

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PDX Model Summary
Model Details	Model ID (Previous ID) TM00112 (BR1172F) Initial Diagnosis Invasive ductal carcinoma Final Diagnosis Invasive ductal carcinoma Stage/Grade AJCC IIIC / Grade:3 Primary Site Breast Sample Site Lymph node Tumor Type Metastatic
Patient	Sex Female Age (at time of tissue collection) 65 Race/Ethnicity White / Not Reported Treatment Naïve? No Current Smoker/Former Smoker Unknown / Unknown
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site no data

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: hu133, stRNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample BR1172F146P0 from passage P0 has a TMB score of 7.27 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:BR1172F146P0 from passage P0 Score:MSI-S
Gene Fusion	no data

Model Characterization

Histology

Summary:
P0 pathology consistent with invasive ductal carcinoma. P2 pathology consistent with carcinoma. AR staining for P2 was cytoplasmic, only nuclear staining is considered positive in breast cancer.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00112. Small nests of pleomorphic epithelial cells in a desmoplastic stroma.	P0 tumor #146 for PDX model TM00112. Small nests of pleomorphic epithelial cells in a desmoplastic stroma.
P0 tumor #146 for TM00112; ER marker positive.	P1 tumor #146_412 for PDX model TM00112.
P1 tumor #146_412 for PDX model TM00112; AR negative	P1 tumor #146_412 for PDX model TM00112; PR marker
P1 tumor #146_412 for PDX model TM00112; ER positive	P1 tumor #146_412 for PDX model TM00112; Erbb2 (Her2) negative
P2 tumor F1461 ID014 for PDX model TM00112 stained for H&E.	P2 tumor F1461 ID014 for PDX model TM00112 stained for AE1AE3. Staining was positive.
P2 tumor F1461 ID014 for PDX model TM00112 stained for CD45. Staining was negative.	P2 tumor F1461 ID014 for PDX model TM00112 stained for Ki67. Staining was positive.
P2 tumor F1461 ID014 for PDX model TM00112 stained for ER. Staining was positive.	P2 tumor F1461 ID014 for PDX model TM00112 stained for PR. Staining was positive.
P2 tumor F1461 ID014 for PDX model TM00112 stained for ERBB2 (HER2). Staining was negative.	P2 tumor F1461 ID014 for PDX model TM00112 stained for AR. Staining was negative.