PDX Model DetailsTM00170

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00170 (CN1572F)
Initial Diagnosis
adenocarcinoma
Final Diagnosis
adenocarcinoma
Stage/Grade
AJCC IV /
Primary Site
Colon
Sample Site
Liver
Tumor Type
Metastatic

Patient

Sex
Male
Age (at time of tissue collection)
30
Race/Ethnicity
White / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 2.43
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:CN1572F2026P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0, P2 pathology consistent with colonic adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F2026 for PDX model TM00170 stained for H&E.

P2 tumor F2026 ID001 for PDX model TM00170 stained for H&E.

P2 tumor F2026 ID001 for PDX model TM00170 stained for AE1AE3. Staining was positive.

P2 tumor F2026 ID001 for PDX model TM00170 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots

no data