PDX Model DetailsTM00170

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Model Details

Model ID (Previous ID)
TM00170 (CN1572F)
Primary Site
Colon
Tumor Site
Liver
Tumor Type
Metastatic
Initial Diagnosis
adenocarcinoma
Final Diagnosis
adenocarcinoma
Stage/Grade
AJCC IV /

Patient

Sex
Male
Age
30
Race/Ethnicity
White / Not Reported
Treatment Naïve
No

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 2.43
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:CN1572F2026P0     Score:MSI-S

Variant Summary

Gene Expression

Platforms: hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
P0, P2 pathology consistent with colonic adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F2026 for PDX model TM00170 stained for H&E.

P2 tumor F2026 ID001 for PDX model TM00170 stained for H&E.

P2 tumor F2026 ID001 for PDX model TM00170 stained for AE1AE3. Staining was positive.

P2 tumor F2026 ID001 for PDX model TM00170 stained for CD45. Staining was negative.

Dosing Studies