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Last Database Update
2019-09-15
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00170 Previous ID:CN1572F
Primary Site:Colon Initial Diagnosis:adenocarcinoma Final Diagnosis:adenocarcinoma
Tumor Site:Liver Tumor Type:Metastatic Stage / Grade:AJCC IV /
Patient
Sex:Male Age:30 Race / Ethnicity:White / Not Reported
Treatment Naive:No
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample from passage P0 has a TMB score of 2.43
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Variant Summary Help

Gene Expression Help Platforms:hu133, stRNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
Pathology consistent with colonic adenocarcinoma, fidelity to P2.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F2026 for PDX model TM00170 stained for H&E.

P2 tumor F2026 ID001 for PDX model TM00170 stained for H&E.

P2 tumor F2026 ID001 for PDX model TM00170 stained for AE1AE3. Staining was positive.

P2 tumor F2026 ID001 for PDX model TM00170 stained for CD45. Staining was negative.
Dosing Studies: