PDX Model DetailsTM00185

Request information on the availability of this model.

PDX Model Summary

Model Details

Model ID (Previous ID)
TM00185 (LG0476F)
Initial Diagnosis
Lung squamous cell carcinoma
Final Diagnosis
Lung squamous cell carcinoma
Stage/Grade
AJCC III /
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Publications citing this model

Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient

Sex
Male
Age (at time of tissue collection)
57
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hg10st, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

no CNV data

CNV Plots

no CNV plots

Tumor Mutation Burden

Sample LG0476F210P0 from passage P0 has a TMB score of 4.85
Sample LG0476F211P0000P1 from passage P1 has a TMB score of 4.04
Sample LG0476F211P0000P1001P2 from passage P2 has a TMB score of 4.04
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:LG0476F210P0 from passage P0     Score:MSI-S
Sample:LG0476F211P0000P1 from passage P1     Score:MSI-S
Sample:LG0476F211P0000P1001P2 from passage P2     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0 pathology consistent with squamous cell carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00185. Nests of pleomorphic squamous cells in a desmoplastic stroma.

Patient tumor for TM00185; IHC positive for human Ki67. Note Ki67 stained image with 30% of tumor cells positive along the growing edges of the tumor.

P0 tumor #211 for PDX model TM00185.

P0 tumor #211 for PDX model TM00185; IHC positive for human Ki67. Note Ki67 stained image with 30% of tumor cells positive along the growing edges of the tumor.

Dosing Studies

Circos Plots

no data