PDX Model DetailsTM00193

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00193 (LG0591F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IIIA /
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
59
Race/Ethnicity
White / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hg10st

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample LG0591F709P0 from passage P0 has a TMB score of 4.85
Sample LG0591F709P5 from passage P5 has a TMB score of 5.66
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG0591F709P0 from passage P0     Score:MSI-S
Sample:LG0591F709P5 from passage P5     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
The P0 tumor architecture is that of smaller glands and single cells compared to the patient tumor; however, the individual cell morphology is very similar.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00193. Large irregular glands lined by moderately pleomorphic nuclei and pink cytoplasm in desmoplastic stroma.
P0 tumor #709 for PDX model TM00193. Small irregular glands and single cells with moderately pleomorphic nuclei and pink cytoplasm.

Dosing Studies

Circos Plots

 no data