PDX Model DetailsTM00196

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00196 (LG0645F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC II /
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
77
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hg10st, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample LG0645F826P0000P1 from passage P1 has a TMB score of 13.73
Sample LG0645F826P0005P1 from passage P1 has a TMB score of 13.73
Sample LG0645F829P0 from passage P0 has a TMB score of 13.73
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG0645F826P0000P1 from passage P1     Score:MSI-S
Sample:LG0645F826P0005P1 from passage P1     Score:MSI-S
Sample:LG0645F829P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00196 stained for H&E.
P0 tumor F826 for PDX model TM00196 stained for H&E.

P0 tumor F826 for PDX model TM00196 stained for vimentin. Staining was positive in stromal cells.
P2 tumor F826 ID015 for PDX model TM00196 stained for H&E.

P2 tumor F826 ID015 for PDX model TM00196 stained for AE1AE3. Staining was positive.
P2 tumor F826 ID015 for PDX model TM00196 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots

 no data