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Last Database Update
2019-09-15
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00199 Previous ID:LG0703F
Primary Site:Lung Initial Diagnosis:lung adenocarcinoma Final Diagnosis:lung adenocarcinoma
Tumor Site:Lung Tumor Type:Metastatic Stage / Grade:AJCC IV / Grade:2
Patient
Sex:Female Age:44 Race / Ethnicity:Asian or Pacific Islander / Not Reported
Treatment Naive:No
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Core needle biopsy
Publications citing this model
Tumor Mutation Burden
Sample from passage P0 has a TMB score of 8.08
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Variant Summary Help

Gene Expression Help Platforms:RNA_Seq, hg10st
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
P2 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor #940_001 for PDX model TM00199.

P1 tumor #940_006 for PDX model TM00199.

P2 tumor F940 ID013 for PDX model TM00199 stained for H&E.

P2 tumor F940 ID013 for PDX model TM00199 stained for AE1/AE3. Staining was positive.

P2 tumor F940 ID013 for PDX model TM00199 stained for CD45. Staining was negative.

P2 tumor F940 ID013 for PDX model TM00199 stained for Ki67. Staining was positive.
Dosing Studies: