PDX Model DetailsTM00199

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Model Details

Model ID (Previous ID)
TM00199 (LG0703F)
Primary Site
Lung
Tumor Site
Lung
Tumor Type
Metastatic
Initial Diagnosis
lung adenocarcinoma
Final Diagnosis
lung adenocarcinoma
Stage/Grade
AJCC IV / Grade:2

Publications citing this model

Phillips, AC; et al. ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope. Molecular Cancer Therapeutics 2016;15(4), 661-669. DOI:10.1158/1535-7163.MCT-15-0901

Patient

Sex
Female
Age
44
Race/Ethnicity
Asian or Pacific Islander / Not Reported
Treatment Naïve
No

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Core needle biopsy

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 7.27
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:LG0703F948P0     Score:MSI-S

Variant Summary

Gene Expression

Platforms: RNA_Seq, hg10st

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
P2 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor #940_001 for PDX model TM00199.

P1 tumor #940_006 for PDX model TM00199.

P2 tumor F940 ID013 for PDX model TM00199 stained for H&E.

P2 tumor F940 ID013 for PDX model TM00199 stained for AE1/AE3. Staining was positive.

P2 tumor F940 ID013 for PDX model TM00199 stained for CD45. Staining was negative.

P2 tumor F940 ID013 for PDX model TM00199 stained for Ki67. Staining was positive.

Dosing Studies