PDX Model DetailsTM00199

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00199 (LG0703F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IV / Grade:2
Primary Site
Lung
Sample Site
Lung
Tumor Type
Metastatic

Publications citing this model

Phillips, AC; et al. ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope. Molecular Cancer Therapeutics 2016;15(4), 661-669. DOI:10.1158/1535-7163.MCT-15-0901

Patient

Sex
Female
Age (at time of tissue collection)
44
Race/Ethnicity
Asian or Pacific Islander / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
No / No

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Core needle biopsy
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hg10st

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample LG0703F948P0 from passage P0 has a TMB score of 7.27
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:LG0703F948P0 from passage P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P2 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor #940_001 for PDX model TM00199.

P1 tumor #940_006 for PDX model TM00199.

P2 tumor F940 ID013 for PDX model TM00199 stained for H&E.

P2 tumor F940 ID013 for PDX model TM00199 stained for AE1/AE3. Staining was positive.

P2 tumor F940 ID013 for PDX model TM00199 stained for CD45. Staining was negative.

P2 tumor F940 ID013 for PDX model TM00199 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

no data