PDX Model DetailsTM00203

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00203 (LG0801F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IV /
Primary Site
Lung
Sample Site
Lung
Tumor Type
Metastatic

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
69
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Core needle biopsy
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hg10st

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

no CNV data

CNV Plots

no CNV plots

Tumor Mutation Burden
Sample LG0801F1250P0 from passage P0 has a TMB score of 30.69
Sample LG0801F725P0000P1000P2000P3000P4074P5 from passage P5 has a TMB score of 26.65
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG0801F1250P0 from passage P0     Score:MSI-S
Sample:LG0801F725P0000P1000P2000P3000P4074P5 from passage P5     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P1 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

Patient tumor for PDX model TM00203.
P0 tumor #1250 for PDX model TM00203.

P1 tumor #1250_007 for PDX model TM00203.
P1 tumor F1250 ID004 for PDX model TM00203 stained for H&E.

P1 tumor F1250 ID004 for PDX model TM00203 stained for AE1/AE3. Staining was positive.
P1 tumor F1250 ID004 for PDX model TM00203 stained for CD45. Staining was negative.

P1 tumor F1250 ID004 for PDX model TM00203 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data