PDX Model DetailsTM00204

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00204 (LG0807F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IV /
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Patient
Sex
Female
Age (at time of tissue collection)
63
Race/Ethnicity
White / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hg10st, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

no CNV data

CNV Plots

no CNV plots

Tumor Mutation Burden
Sample LG0807F1297P0 from passage P0 has a TMB score of 4.04
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG0807F1297P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P2 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00204.
P1 tumor #1297_113 for PDX model TM00204.

P2 tumor F1297 ID013 for PDX model TM00204 stained for H&E.
P2 tumor F1297 ID015 for PDX model TM00204 stained forH&E.

P2 tumor F1297 ID013 for PDX model TM00204 stained for AE1AE3. Staining was positive.
P2 tumor F1297 ID015 for PDX model TM00204 stained for AE1AE3. Staining was positive.

P2 tumor F1297 ID013 for PDX model TM00204 stained for CD45. Staining was negative.
P2 tumor F1297 ID015 for PDX model TM00204 stained for CD45. Staining was negative.

P2 tumor F1297 ID013 for PDX model TM00204 stained for Ki67. Staining was positive.
P2 tumor F1297 ID015 for PDX model TM00204 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data