PDX Model DetailsTM00206

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00206 (LG0812PE)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IV /
Primary Site
Lung
Sample Site
Pleural cavity
Tumor Type
Metastatic

Patient

Sex
Female
Age (at time of tissue collection)
57
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / No

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Pleural effusion
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hg10st, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample LG0812PE1330P0 from passage P0 has a TMB score of 8.89
Sample LG0812PE1332P0 from passage P0 has a TMB score of 8.08
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:LG0812PE1330P0 from passage P0     Score:MSI-S
Sample:LG0812PE1332P0 from passage P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P2 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00206.

P0 tumor #1326 for PDX model TM000206.

P0 tumor #1330 for PDX model TM00206.

P2 (PE, pleural effusion) tumor 1334 ID013 for PDX model TM00206 stained for H&E.

P2 (PE, pleural effusion) tumor 1334 ID013 for PDX model TM00206 stained for AE1AE3. Staining was positive.

P2 (PE, pleural effusion) tumor 1334 ID013 for PDX model TM00206 stained for CD45. Staining was negative.

P2 (PE, pleural effusion) tumor 1334 ID013 for PDX model TM00206 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

no data