PDX Model DetailsTM00212

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00212 (LG0978F)
Initial Diagnosis
Large cell neuroendocrine carcinoma
Final Diagnosis
Large cell neuroendocrine carcinoma
Stage/Grade
AJCC IIIB / Grade:3
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Publications citing this model

 Wang, M; et al. Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. 2018 FASEB 2018 Mar;32(3):1537-1549.  10.1096/fj.201700740R
Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Male
Age (at time of tissue collection)
53
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Yes / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hg10st, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample LG0978F1565P0 from passage P0 has a TMB score of 7.27
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG0978F1565P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P2 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

Patient tumor for PDX model TM00212.
Patient tumor for PDX model TM00212; Synaptophysin marker

Patient tumor for PDX model TM00212; Chromogranin A marker
Patient tumor for PDX model TM00212; Chromogranin A marker

P0 tumor #1563 for PDX model TM00212.
P0 tumor #1565 for PDX model TM00212; Synaptophysin marker

P0 tumor #1565 for PDX model TM00212; Chromogranin A marker
P2 tumor F1545 ID012 for PDX model TM00212 stained for H&E.

P2 tumor F1545 ID012 for PDX model TM00212 stained for AE1AE3. Staining was positive.
P2 tumor F1545 ID012 for PDX model TM00212 stained for CD45. Staining was negative.

P2 tumor F1545 ID012 for PDX model TM00212 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data