PDX Model DetailsTM00222

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00222 (LG1102F)
Initial Diagnosis
Pleomorphic carcinoma
Final Diagnosis
Pleomorphic carcinoma
Stage/Grade
AJCC IIIA /
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Related Models

PDX models TM00222 and TM00302 originated from the same patient.

Patient

Sex
Female
Age (at time of tissue collection)
52
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

no data

CNV Plots

no data

Tumor Mutation Burden

Sample LG1102F1846P0 from passage P0 has a TMB score of 10.5
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:LG1102F1846P0 from passage P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0 pathology consistent with pleomorphic carcinoma. P2 pathology consistent with spindle cell tumor, AE1/AE3 appears to be positive in P2.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00222.Nests of very large, pleomorphic cells with large vesicular nuclei and foci of central necrosis.

P0 tumor # 1845 for PDX model TM00222.Sheets of large pleomorphic cells.

P1 tumor F18461 P2 ID002 for PDX model TM00222 stained for H&E.

P1 tumor F18461 P2 ID002 for PDX model TM00222 stained for AE1AE3. Staining was positive.

P1 tumor F18461 P2 ID002 for PDX model TM00222 stained for CD45. Staining was negative

Dosing Studies

Circos Plots

no data