PDX Model DetailsTM00226

PDX Model Summary
Model Details	Model ID (Previous ID) TM00226 (LG1179F) Initial Diagnosis Lung adenocarcinoma Final Diagnosis Lung adenocarcinoma Stage/Grade AJCC IB / Grade:3 Primary Site Lung Sample Site Lung Tumor Type Primary Malignancy
Publications citing this model	Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586. 10.7717/peerj.6586
Patient	Sex Female Age (at time of tissue collection) 49 Race/Ethnicity White / Not Hispanic or Latino Treatment Naïve? Yes Current Smoker/Former Smoker Yes / Unknown
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site no data

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: RNA_Seq, hu133 Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample LG1179F2089P0 from passage P0 has a TMB score of 46.84 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:LG1179F2089P0 from passage P0 Score:MSI-S
Gene Fusion	no data

Model Characterization

Summary:
P0 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00226. Nests of pleomorphic cells in irregular glands.

P0 tumor #2089 for PDX model TM00226. Sheets of pleomorphic cells with vacuolated cytoplasm.

no data