PDX Model DetailsTM00229

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PDX Model Summary
Model Details	Model ID (Previous ID) TM00229 (LG1189F) Initial Diagnosis Lung adenocarcinoma Final Diagnosis Lung adenocarcinoma Stage/Grade AJCC IV / Grade:3 Primary Site Lung Sample Site Lung Tumor Type Primary Malignancy
Patient	Sex Female Age (at time of tissue collection) 58 Race/Ethnicity White / Not Hispanic or Latino Treatment Naïve? Yes Current Smoker/Former Smoker Unknown / Yes
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site no data

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: hu133, stRNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample LG1189F1951P0 from passage P0 has a TMB score of 15.35 Sample LG1189F1952P0 from passage P0 has a TMB score of 14.54 Sample LG1189F1952P0002P1 from passage P1 has a TMB score of 12.12 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:LG1189F1951P0 from passage P0 Score:MSI-S Sample:LG1189F1952P0 from passage P0 Score:MSI-S Sample:LG1189F1952P0002P1 from passage P1 Score:MSI-S
Gene Fusion	no data

Model Characterization

Histology

Summary:
PT is high grade carcinoma. P1 pathology consistent with high grade carcinoma, non small cell, favor adenocarcinoma. P2 pathology consistent with poorly differentiated carcinoma. P4 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

PT tumor for PDX model TM00229 stained for H&E.	P1 tumor ID280 for PDX model TM00229 stained for H&E.
P2 tumor F1952 ID014 for PDX model TM00229 stained for H&E.	P2 tumor F1952 ID014 for PDX model TM00229 stained for AE1AE3. Staining was positive.
P2 tumor F1952 ID014 for PDX model TM00229 stained for CD45. Staining was negative.	P2 tumor F1952 ID014 for PDX model TM00229 stained for Ki67. Staining was positive.
P4 tumor F1952 ID023 for PDX model TM00229 stained for H&E.	P4 tumor F1952 ID023 for PDX model TM00229 stained for AE1/AE3. Staining was positive.
P4 tumor F1952 ID023 for PDX model TM00229 stained for CD45. Staining was negative.	P4 tumor F1952 ID023 for PDX model TM00229 stained for Ki67. Staining was positive.