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Last Database Update
2019-09-15
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00231 Previous ID:LG1197F
Primary Site:Lung Initial Diagnosis:lung squamous cell carcinoma Final Diagnosis:lung squamous cell carcinoma
Tumor Site:Lung Tumor Type:Primary Malignancy Stage / Grade:AJCC IB / Grade:2
Patient
Sex:Male Age:73 Race / Ethnicity:White / Not Hispanic or Latino
Treatment Naive:Yes
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample from passage P0 has a TMB score of 8.08
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Variant Summary Help

Gene Expression Help Platforms:hu133, stRNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
P1 pathology consistent with squamous cell carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis for P1.

Patient tumor for PDX model TM00231.

P0 tumor #382 for PDX model TM00231.

P0 tumor #382 for PDX model TM00231; TTF1 marker

P0 tumor #382 for PDX model TM00231; p63 marker

P0 tumor #382 for PDX model TM00231; CK7 marker

P0 tumor #382 for PDX model TM00231; CK5 marker

P1 tumor F385 P1 005 for PDX model TM00231 stained for H&E.

P1 tumor F385 P1 005 for PDX model TM00231 stained for AE1AE3. Staining was positive.

P1 tumor F385 P1 005 for PDX model TM00231 stained for Ki67. Staining was positive.

P1 tumor F385 P1 005 for PDX model TM00231 stained for CD45. Staining was negative.
Dosing Studies: