PDX Model DetailsTM00233

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00233 (LG1202F)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IIIA / Grade:3
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Related Models

PDX models TM00233 and TM01357 originated from the same patient.

Publications citing this model

Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient

Sex
Female
Age (at time of tissue collection)
47
Race/Ethnicity
White / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Yes / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample LG1202F380P0059P1 from passage P1 has a TMB score of 13.73
Sample LG1202F380P0062P1 from passage P1 has a TMB score of 15.35
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:LG1202F380P0059P1 from passage P1     Score:MSI-S
Sample:LG1202F380P0062P1 from passage P1     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor #380 for PDX model TM00233; Synaptophysin marker

P0 tumor #380 for PDX model TM00233; IHC for Chromogranin A. Sheets of pleomorphic cells with vacuolated cytoplasm. Consistent with poorly differentiated adenocarcinoma.

Dosing Studies

Circos Plots

no data