PDX Model DetailsTM00233

Request information on the availability of this model.

PDX Model Summary

Model Details

Model ID (Previous ID)
TM00233 (LG1202F)
Initial Diagnosis
lung adenocarcinoma
Final Diagnosis
lung adenocarcinoma
Stage/Grade
AJCC IIIA / Grade:3
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Related Models

PDX models TM00233 and TM01357 originated from the same patient.

Patient

Sex
Female
Age (at time of tissue collection)
47
Race/Ethnicity
White / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Yes / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample
Sample from passage P1 has a TMB score of 15.35
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Samples
Sample:LG1202F380P0062P1     Score:MSI-S
Sample:LG1202F380P0059P1     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor #380 for PDX model TM00233; Synaptophysin marker

P0 tumor #380 for PDX model TM00233; IHC for Chromogranin A. Sheets of pleomorphic cells with vacuolated cytoplasm. Consistent with poorly differentiated adenocarcinoma.

Dosing Studies

Circos Plots

no data