PDX Model DetailsTM00233

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Model Details

Model ID (Previous ID)
TM00233 (LG1202F)
Primary Site
Lung
Tumor Site
Lung
Tumor Type
Primary Malignancy
Initial Diagnosis
lung adenocarcinoma
Final Diagnosis
lung adenocarcinoma
Stage/Grade
AJCC IIIA / Grade:3
Related Models
PDX models TM00233 and TM01357 originated from the same patient.

Patient

Sex
Female
Age
47
Race/Ethnicity
White / Not Reported
Treatment Naïve
No

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)

Tumor Mutation Burden

Sample
Sample from passage P1 has a TMB score of 15.35
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:LG1202F380P0062P1     Score:MSI-S
Sample:LG1202F380P0059P1     Score:MSI-S

Variant Summary

Gene Expression

Platforms: hu133

Gene CNV

CNV Plots

Model Characterization

Histology: Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor #380 for PDX model TM00233; Synaptophysin marker

P0 tumor #380 for PDX model TM00233; IHC for Chromogranin A. Sheets of pleomorphic cells with vacuolated cytoplasm. Consistent with poorly differentiated adenocarcinoma.

Dosing Studies