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Last Database Update
2019-09-15
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00233 Previous ID:LG1202F
Primary Site:Lung Initial Diagnosis:lung adenocarcinoma Final Diagnosis:lung adenocarcinoma
Tumor Site:Lung Tumor Type:Primary Malignancy Stage / Grade:AJCC IIIA / Grade:3
Related Models: PDX models TM00233 and TM01357 originated from the same patient.
Patient
Sex:Female Age:47 Race / Ethnicity:White / Not Reported
Treatment Naive:No
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample from passage P1 has a TMB score of 14.54
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Variant Summary Help

Gene Expression Help Platforms:hu133
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor #380 for PDX model TM00233; Synaptophysin marker

P0 tumor #380 for PDX model TM00233; IHC for Chromogranin A. Sheets of pleomorphic cells with vacuolated cytoplasm. Consistent with poorly differentiated adenocarcinoma.
Dosing Studies: