PDX Model DetailsTM00246

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00246 (LG1237F)
Initial Diagnosis
Lung mixed small cell and squamous cell carcinoma
Final Diagnosis
Lung mixed small cell and squamous cell carcinoma
Stage/Grade
AJCC IV / Grade:4
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Male
Age (at time of tissue collection)
82
Race/Ethnicity
White / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample LG1237F081P0 from passage P0 has a TMB score of 10.5
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG1237F081P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
Patient tumor had both small cell carcinoma and squamous cell carcinoma. P0 and P1 pathology consistent with squamous cell carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00246 stained for H&E.
Patient small cell carcinoma tumor for PDX model TM00246 stained for H&E.

P0 tumor F079 for PDX model TM00246 stained for H&E.
P1 tumor F078 P006 for PDX model TM00246 stained for H&E.

P1 tumor F078 P006 for PDX model TM00246 stained for AE1AE3. Staining was positive.

Dosing Studies

Circos Plots

 no data