PDX Model DetailsTM00298

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00298 (PR1996F)
Initial Diagnosis
Adenocarcinoma
Final Diagnosis
Adenocarcinoma
Stage/Grade
Not Specified / GG1:5,GG2:5,GG3:
Primary Site
Prostate gland
Sample Site
Prostate gland
Tumor Type
Primary Malignancy

Publications citing this model

 Jin, L; et al. Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer. Cancer Res. 2017 Oct 15;77(20):5564-5575.  10.1016/j.ccell.2018.06.012
Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Male
Age (at time of tissue collection)
71
Race/Ethnicity
White / Hispanic
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample PR1996F336P0 from passage P0 has a TMB score of 29.88
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:PR1996F336P0 from passage P0     Score:MSI-H

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P4 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor #336 for PDX model TM00298.
P0 tumor #336 for PDX model TM00298; PSA marker

P0 tumor #336 for PDX model TM00298; AR marker
P4 tumor F336 ID023 for PDX model TM00298 stained for H&E.

P4 tumor F336 ID023 for PDX model TM00298 stained for AE1AE3. Staining was positive.
P4 tumor F336 ID023 for PDX model TM00298 stained for CD45. Staining was negative.

P4 tumor F336 ID023 for PDX model TM00298 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data