PDX Model DetailsTM00298

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Model Details

Model ID (Previous ID)
TM00298 (PR1996F)
Primary Site
Prostate gland
Tumor Site
Prostate gland
Tumor Type
Primary Malignancy
Initial Diagnosis
adenocarcinoma
Final Diagnosis
adenocarcinoma
Stage/Grade
Not Specified / GG1:5,GG2:5,GG3:

Patient

Sex
Male
Age
71
Race/Ethnicity
White / Hispanic
Treatment Naïve
No

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)

Variant Summary

Gene Expression

Platforms: hu133

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
P4 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor #336 for PDX model TM00298.

P0 tumor #336 for PDX model TM00298; PSA marker

P0 tumor #336 for PDX model TM00298; AR marker

P4 tumor F336 ID023 for PDX model TM00298 stained for H&E.

P4 tumor F336 ID023 for PDX model TM00298 stained for AE1AE3. Staining was positive.

P4 tumor F336 ID023 for PDX model TM00298 stained for CD45. Staining was negative.

P4 tumor F336 ID023 for PDX model TM00298 stained for Ki67. Staining was positive.

Dosing Studies