PDX Model DetailsTM00298

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00298 (PR1996F)
Initial Diagnosis
adenocarcinoma
Final Diagnosis
adenocarcinoma
Stage/Grade
Not Specified / GG1:5,GG2:5,GG3:
Primary Site
Prostate gland
Sample Site
Prostate gland
Tumor Type
Primary Malignancy

Patient

Sex
Male
Age (at time of tissue collection)
71
Race/Ethnicity
White / Hispanic
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

no data

Microsatellite Instability

no data

Gene Fusion

no data

Model Characterization

Histology

Summary:
P4 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor #336 for PDX model TM00298.

P0 tumor #336 for PDX model TM00298; PSA marker

P0 tumor #336 for PDX model TM00298; AR marker

P4 tumor F336 ID023 for PDX model TM00298 stained for H&E.

P4 tumor F336 ID023 for PDX model TM00298 stained for AE1AE3. Staining was positive.

P4 tumor F336 ID023 for PDX model TM00298 stained for CD45. Staining was negative.

P4 tumor F336 ID023 for PDX model TM00298 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

no data