PDX Model DetailsTM00324

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00324 (OV2022F)
Initial Diagnosis
Papillary serous adenocarcinoma
Final Diagnosis
Ovary serous adenocarcinoma
Stage/Grade
AJCC IV / Grade:3
Primary Site
Ovary
Sample Site
Omentum
Tumor Type
Metastatic

Patient
Sex
Female
Age (at time of tissue collection)
65
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Fine needle aspirate
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample OV2022F394P0000P1002P2 from passage P2 has a TMB score of 1.62
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:OV2022F394P0000P1002P2 from passage P2     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0, P1, P2 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

P0 tumor F394 for PDX model TM00324 stained for H&E.
P0 tumor F394 for PDX model TM00324 stained for AE1AE3. Staining was positive

P0 tumor F394 for PDX model TM00324 stained for Ki67. Staining was positive
P0 tumor F394 for PDX model TM00324 stained for CD45. Staining was negative.

P1 tumor F394 ID014 for PDX model TM00324 stained for H&E.
P1 tumor F394 ID014 for PDX model TM00324 stained for AE1AE3. Staining was positive.

P1 tumor F394 ID014 for PDX model TM00324 stained for Ki67. Staining was positive.
P1 tumor F394 ID014 for PDX model TM00324 stained for CD45. Staining was negative.

P2 tumor F394 ID013 for PDX model TM00324 stained for H&E.
P2 tumor F394 ID013 for PDX model TM00324 stained for AE1AE3. Staining was positive.

P2 tumor F394 ID013 for PDX model TM00324 stained for CD45. Staining was negative.
P2 tumor F394 ID013 for PDX model TM00324 stained for Ki67. Staining was positive.

Dosing Studies

Circos Plots

 no data