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Last Database Update
2020-02-16
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00327 Previous ID:OV12JX01F
Primary Site:Ovary Initial Diagnosis:ovary serous adenocarcinoma Final Diagnosis:ovary papillary carcinoma
Tumor Site:Omentum Tumor Type:Metastatic Stage / Grade:AJCC IIIC / Grade:high
Patient
Sex:Female Age:50 Race / Ethnicity:Not Reported / Not Reported
Treatment Naive:Unknown
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Not Specified
Tumor Mutation Burden
Sample from passage P0 has a TMB score of 4.04
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Microsatellite Instability Help
Sample:OVJX01FPT     Score:MSI-S
Sample:OV12JX01F017P0     Score:MSI-S
Variant Summary Help

Gene Expression Help Platforms:hu133
Gene CNV Help
CNV Plots Help
No gene CNV plots currently available.
Model Characterization
Histology: Summary:
Po and P2 pathology consistent with high grade ovarian carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F021 for PDX model TM00327 stained for H&E.

P0 tumor F021 for PDX model TM00327 stained for CD45. Staining was negative.

P0 tumor F021 for PDX model TM00327 stained for Ki67. Staining was positive.

P2 tumor F022 ID007for PDX model TM00327 stained for H&E.

P0 tumor F022 ID007 for PDX model TM00327 stained for CD45. Staining was negative.

P0 tumor F022 ID007 for PDX model TM00327 stained for Ki67. Staining was positive.