PDX Model DetailsTM00334

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PDX Model Summary
Model Details	Model ID (Previous ID) TM00334 (OV1110F) Initial Diagnosis Carcinosarcoma Final Diagnosis Ovarian carcinosarcoma Stage/Grade AJCC IIIC / Primary Site Ovary Sample Site Ovary Tumor Type Primary Malignancy
Patient	Sex Female Age (at time of tissue collection) 52 Race/Ethnicity Asian or Pacific Islander / Not Hispanic or Latino Treatment Naïve? Yes Current Smoker/Former Smoker Unknown / Unknown
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Core needle biopsy Engraftment Site no data

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: hg10st
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample OV1110F024P0 from passage P0 has a TMB score of 4.04 Sample OV1110F024P0000P1008P2 from passage P2 has a TMB score of 4.04 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:OV1110F024P0 from passage P0 Score:MSI-S Sample:OV1110F024P0000P1008P2 from passage P2 Score:MSI-S
Gene Fusion	no data

Model Characterization

Histology

Summary:
P1, P2 ID006 pathology consistent with high grade carcinoma of ovary. P2 ID013 pathology consistent with poorly differentiated carcinoma. P3 pathology consistent with high grade carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor F024 ID145 for PDX model TM00334 stained for H&E.	P2 tumor F024 ID006 for PDX model TM00334 stained for H&E.
P2 tumor F024 ID013 for PDX model TM00334 stained for H&E.	P2 tumor F024 ID006 for PDX model TM00334 stained for AE1AE3. Staining was positive.
P2 tumor F024 ID013 for PDX model TM00334 stained for AE1AE3. Staining was positive.	P2 tumor F024 ID006 for PDX model TM00334 stained for CD45. Staining was negative.
P2 tumor F024 ID013 for PDX model TM00334 stained for CD45. Staining was negative.	P2 tumor F024 ID013 for PDX model TM00334 stained for Ki67. Staining was positive.
P3 tumor F024 ID019 for PDX model TM00334 stained for H&E.	P3 tumor F024 ID019 for PDX model TM00334 stained for AE1/AE3. Staining was positive.
P3 tumor F024 ID019 for PDX model TM00334 stained for CD45. Staining was negative.	P3 tumor F024 ID019 for PDX model TM00334 stained for Ki67. Staining was positive.