PDX Model DetailsTM00335

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00335 (OV1828F)
Initial Diagnosis
papillary serous adenocarcinoma
Final Diagnosis
papillary serous adenocarcinoma
Stage/Grade
III /
Primary Site
Ovary
Sample Site
Ovary
Tumor Type
Primary Malignancy

Patient

Sex
Female
Age (at time of tissue collection)
89
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Samples
Sample from passage P0 has a TMB score of 4.85
Sample from passage P2 has a TMB score of 3.23
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Samples
Sample:OV1828F082P0000P1008P2     Score:MSI-S
Sample:OV1828F081P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P6 pathology consistent with ovarian serous carcinoma, fidelity to P6.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F082 for PDX model TM00335 stained for H&E.

P6 tumor F082 ID004 for PDX model TM00335 stained for H&E.

Dosing Studies

Circos Plots

no data