PDX Model DetailsTM00335

Request more information on this PDX model.

Model Details

Model ID (Previous ID)
TM00335 (OV1828F)
Primary Site
Ovary
Tumor Site
Ovary
Tumor Type
Primary Malignancy
Initial Diagnosis
papillary serous adenocarcinoma
Final Diagnosis
papillary serous adenocarcinoma
Stage/Grade
III /

Patient

Sex
Female
Age
89
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve
Yes

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 4.85
Sample from passage P2 has a TMB score of 3.23
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:OV1828F082P0000P1008P2     Score:MSI-S
Sample:OV1828F081P0     Score:MSI-S

Variant Summary

Gene Expression

Platforms: hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
Pathology consistent with ovarian serous carcinoma, fidelity to P6.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F082 for PDX model TM00335 stained for H&E.

P6 tumor F082 ID004 for PDX model TM00335 stained for H&E.

Dosing Studies