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Last Database Update
2019-09-15
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00335 Previous ID:OV1828F
Primary Site:Ovary Initial Diagnosis:papillary serous adenocarcinoma Final Diagnosis:papillary serous adenocarcinoma
Tumor Site:Ovary Tumor Type:Primary Malignancy Stage / Grade:III /
Patient
Sex:Female Age:89 Race / Ethnicity:Not Reported / Not Reported
Treatment Naive:Yes
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample from passage P0 has a TMB score of 6.46
Sample from passage P2 has a TMB score of 6.46
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Variant Summary Help

Gene Expression Help Platforms:hu133, stRNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
Pathology consistent with ovarian serous carcinoma, fidelity to P6.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F082 for PDX model TM00335 stained for H&E.

P6 tumor F082 ID004 for PDX model TM00335 stained for H&E.
Dosing Studies: