PDX Model DetailsTM00339

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00339 (SK129862F)
Initial Diagnosis
Melanoma
Final Diagnosis
Melanoma
Stage/Grade
AJCC IV /
Primary Site
Skin
Sample Site
Ovary
Tumor Type
Metastatic

Patient
Sex
Female
Age (at time of tissue collection)
no data
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample SK129862F002P0 from passage P0 has a TMB score of 65.41
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:SK129862F002P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P2 pathology consistent with melanoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P2 tumor F0021 ID013 for PDX model TM00339 stained for H&E.
P2 tumor F0021 ID013 for PDX model TM00339 stained for AE1AE3. Staining was negative.

P2 tumor F0021 ID013 for PDX model TM00339 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots

 no data