PDX Model DetailsTM00355

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00355 (LG0551F)
Initial Diagnosis
Lung squamous cell carcinoma
Final Diagnosis
Lung squamous cell carcinoma
Stage/Grade
Not Specified /
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Male
Age (at time of tissue collection)
73
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hg10st, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample LG0551F0552P0000P1000P2005P3 from passage P3 has a TMB score of 12.12
Sample LG0551F552P0000P12003P2 from passage P2 has a TMB score of 10.5
Sample LG0551F552P0000P1252P2 from passage P2 has a TMB score of 12.12
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG0551F0552P0000P1000P2005P3 from passage P3     Score:MSI-S
Sample:LG0551F552P0000P12003P2 from passage P2     Score:MSI-S
Sample:LG0551F552P0000P1252P2 from passage P2     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0 pathology consistent with squamous cell carcinoma. P3 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00355. Nests of pleomorphic squamous cells in desmoplastic stroma.
P0 tumor #552 for PDX model TM00355. Nests of pleomorphic squamous cells in desmoplastic stroma.

P3 tumor F552 P3 ID001 for PDX model TM00355 stained for H&E.
P3 tumor F552 P3 ID001 for PDX model TM00355 stained for AE1AE3. Staining was positive.

P3 tumor F552 P3 ID001 for PDX model TM00355 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots

 no data