PDX Model DetailsTM00368

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00368 (LY0055F)
Initial Diagnosis
B-cell lymphoma
Final Diagnosis
Diffuse large B-cell lymphoma
Stage/Grade
AJCC IIIA /
Primary Site
Lymph node
Sample Site
Lymph node
Tumor Type
Primary Malignancy

Patient

Sex
Male
Age (at time of tissue collection)
68
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / No

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Biopsy (type unspecified)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hg10st, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample LY0055F667P3 from passage P3 has a TMB score of 9.69
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:LY0055F667P3 from passage P3     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P2 pathology consistent with lymphoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor #667 for PDX model TM00368.

P0 tumor #667 for PDX model TM00368; BCL2

P2 tumor F667 ID043 for PDX model TM00368 stained for H&E.

P2 tumor F668 ID014 for PDX model TM00368 stained for H&E.

P2 tumor F667 ID043 for PDX model TM00368 stained for AE1AE3. Staining was negative.

P2 tumor F668 ID014 for PDX model TM00368 stained for AE1/AE3. Staining was negative.

P2 tumor F667 ID043 for PDX model TM00368 stained for CD45. Staining was positive

P2 tumor F668 ID014 for PDX model TM00368 stained for CD45. Staining was positive.

P2 tumor F667 ID043 for PDX model TM00368 stained for Ki67. Staining was positive

P2 tumor F668 ID014 for PDX model TM00368 stained for Ki67. Staining was positive.

Dosing Studies

no data

Circos Plots


Circos plot for P0 tumor #667 from PDX model TM00368 (aka, LY0055F)