PDX Model DetailsTM00784

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00784 (LG1208aF)
Initial Diagnosis
Lung adenocarcinoma
Final Diagnosis
Lung adenocarcinoma
Stage/Grade
AJCC IV / Grade:3
Primary Site
Lung
Sample Site
Lung
Tumor Type
Primary Malignancy

Publications citing this model

 Wang, M; et al. Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. 2018 FASEB 2018 Mar;32(3):1537-1549.  10.1096/fj.201700740R
Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
42
Race/Ethnicity
Asian or Pacific Islander / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / No

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample LG1208aF003 has a TMB score of 3.23
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG1208aF003     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P1 pathology consistent with spindle cell tumor, possibly Sarcoma. P2 tumor pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor F023 P0087 P1 for PDX model TM00784 stained for H&E.
P1 tumor F023 P0087 P1 for PDX model TM00784 stained for AE1AE3. Staining was negative.

P1 tumor F023 P0087 P1 for PDX model TM00784 stained for CD45. Staining was negative.
P1 tumor F023 P0087 P1 for PDX model TM00784 stained for KI67. Staining was positive.

P2 tumor F025 ID011 P1 for PDX model TM00784 stained for H&E.

Dosing Studies

Circos Plots

 no data