PDX Model DetailsTM00784

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Model Details

Model ID (Previous ID)
TM00784 (LG1208aF)
Primary Site
Lung
Tumor Site
Lung
Tumor Type
Primary Malignancy
Initial Diagnosis
lung adenocarcinoma
Final Diagnosis
lung adenocarcinoma
Stage/Grade
AJCC IV / Grade:3

Patient

Sex
Female
Age
42
Race/Ethnicity
Asian or Pacific Islander / Not Hispanic or Latino
Treatment Naïve
No

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)

Tumor Mutation Burden

Sample
Sample LG1208aF003 has a TMB score of 3.23
Sample LG1208aF116 has a TMB score of 4.85
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:LG1208aF116     Score:MSI-S
Sample:LG1208aF003     Score:MSI-S

Variant Summary

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
P1 pathology consistent with spindle cell tumor, possibly Sarcoma. P2 tumor pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor F023 P0087 P1 for PDX model TM00784 stained for H&E.

P1 tumor F023 P0087 P1 for PDX model TM00784 stained for AE1AE3. Staining was negative.

P1 tumor F023 P0087 P1 for PDX model TM00784 stained for CD45. Staining was negative.

P1 tumor F023 P0087 P1 for PDX model TM00784 stained for KI67. Staining was positive.

P2 tumor F025 ID011 P1 for PDX model TM00784 stained for H&E.

Dosing Studies