PDX Model DetailsTM00784

Model Details	Model ID (Previous ID) TM00784 (LG1208aF) Primary Site Lung Tumor Site Lung Tumor Type Primary Malignancy Initial Diagnosis lung adenocarcinoma Final Diagnosis lung adenocarcinoma Stage/Grade AJCC IV / Grade:3
Patient	Sex Female Age 42 Race/Ethnicity Asian or Pacific Islander / Not Hispanic or Latino Treatment Naïve No
Engraftment Host	Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment)
Tumor Mutation Burden	Sample Sample LG1208aF003 has a TMB score of 3.23 Sample LG1208aF116 has a TMB score of 4.85 TMB Range 0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample Sample:LG1208aF116 Score:MSI-S Sample:LG1208aF003 Score:MSI-S

Variant Summary

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Histology:

Summary:

P1 pathology consistent with spindle cell tumor, possibly Sarcoma. P2 tumor pathology consistent with carcinoma.

Pathologist:

Dr. Regina Gandour-Edwards, University of California, Davis

P1 tumor F023 P0087 P1 for PDX model TM00784 stained for H&E.	P1 tumor F023 P0087 P1 for PDX model TM00784 stained for AE1AE3. Staining was negative.
P1 tumor F023 P0087 P1 for PDX model TM00784 stained for CD45. Staining was negative.	P1 tumor F023 P0087 P1 for PDX model TM00784 stained for KI67. Staining was positive.
P2 tumor F025 ID011 P1 for PDX model TM00784 stained for H&E.