PDX Model DetailsTM00832

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00832 (LG1191aF)
Initial Diagnosis
Lung squamous cell carcinoma
Final Diagnosis
Lung squamous cell carcinoma
Stage/Grade
AJCC IV / Grade:2
Primary Site
Lung
Sample Site
Lung
Tumor Type
Recurrent/Relapse

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
53
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample LG1191aF2114P0 from passage P0 has a TMB score of 13.73
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:LG1191aF2114P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0 pathology consistent with squamous cell carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00832. Nests of pleomorphic cells with clear and eosinophilic cytoplasm.
P0 tumor #2114 for PDX model TM00832. Sheets of highly pleomorphic cells with giant cells and frequent mitoses.

P0 tumor #2114 for PDX model TM00832. IHC for Ki67 showing actively dividing human cells.

Dosing Studies

Circos Plots

 no data