PDX Model DetailsTM00916

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Model Details

Model ID (Previous ID)
TM00916 (OM1058F)
Primary Site
Ovary
Tumor Site
Omentum
Tumor Type
Metastatic
Initial Diagnosis
ovary serous adenocarcinoma
Final Diagnosis
ovary serous adenocarcinoma
Stage/Grade
AJCC IV / Grade:3
Related Models
PDX models TM00916, TM00913 and TM00914 originated from the same patient.

Patient

Sex
Female
Age
68
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve
Yes

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)

Tumor Mutation Burden

Sample
Sample from passage P1 has a TMB score of 4.04
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:OM1058F141P059P1     Score:MSI-S

Variant Summary

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
Ovarian serous carcinoma with fidelity to P1. P2 pathology consistent with serous carcinoma of ovary.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F141 for PDX model TM00916 stained for H&E.

P0 tumor F141 for PDX model TM00916 stained for AE1AE3. Staining was positive

P0 tumor F141 for PDX model TM00916 stained for CD45. Staining was negative.

P1 tumor F141 for PDX model TM00916 stained for H&E.

P2 tumor F142 ID007 for PDX model TM00916 stained for H&E.

Dosing Studies