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Last Database Update
2020-02-16
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00916 Previous ID:OM1058F
Primary Site:Ovary Initial Diagnosis:ovary serous adenocarcinoma Final Diagnosis:ovary serous adenocarcinoma
Tumor Site:Omentum Tumor Type:Metastatic Stage / Grade:AJCC IV / Grade:3
Related Models: PDX models TM00916, TM00913 and TM00914 originated from the same patient.
Patient
Sex:Female Age:68 Race / Ethnicity:White / Not Hispanic or Latino
Treatment Naive:Yes
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample from passage P1 has a TMB score of 4.04
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Microsatellite Instability Help
Sample:OM1058F141P059P1     Score:MSI-S
Variant Summary Help

Gene Expression Help Platforms:RNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
Ovarian serous carcinoma with fidelity to P1. P2 pathology consistent with serous carcinoma of ovary.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F141 for PDX model TM00916 stained for H&E.

P0 tumor F141 for PDX model TM00916 stained for AE1AE3. Staining was positive

P0 tumor F141 for PDX model TM00916 stained for CD45. Staining was negative.

P1 tumor F141 for PDX model TM00916 stained for H&E.

P2 tumor F142 ID007 for PDX model TM00916 stained for H&E.