PDX Model DetailsTM00945

Request information on the availability of this model.

PDX Model Summary

Model Details

Model ID (Previous ID)
TM00945 (LV1028F)
Initial Diagnosis
Colon adenocarcinoma
Final Diagnosis
Colon adenocarcinoma
Stage/Grade
AJCC IV /
Primary Site
Colon
Sample Site
Liver
Tumor Type
Metastatic

Patient

Sex
Male
Age (at time of tissue collection)
no data
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample LV1028F21P0209P1 from passage P1 has a TMB score of 4.04
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:LV1028F21P0209P1 from passage P1     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0 tumor pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor for PDX model TM00945 stained for H&E.

P0 F021 tumor for PDX model TM00945 stained for AE1AE3. Staining was positive.

P0 F021 tumor for PDX model TM00945 stained for CD45. Staining was negative.

P0 F021 tumor for PDX model TM00945 stained for Ki67. Staining was positive.

Dosing Studies

no data

Circos Plots

no data