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Last Database Update
2020-07-05
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00945 Previous ID:LV1028F
Primary Site:Colon Initial Diagnosis:colon adenocarcinoma Final Diagnosis:colon adenocarcinoma
Tumor Site:Liver Tumor Type:Metastatic Stage / Grade:AJCC IV /
Patient
Sex:Male Age: Race / Ethnicity:Not Reported / Not Reported
Treatment Naive:No
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample from passage P1 has a TMB score of 4.04
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Microsatellite Instability Help
Sample:LV1028F21P0209P1     Score:MSI-S
Variant Summary Help

Gene Expression Help Platforms:RNA_Seq
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
P0 tumor pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor for PDX model TM00945 stained for H&E.

P0 F021 tumor for PDX model TM00945 stained for AE1AE3. Staining was positive.

P0 F021 tumor for PDX model TM00945 stained for CD45. Staining was negative.

P0 F021 tumor for PDX model TM00945 stained for Ki67. Staining was positive.