PDX Model DetailsTM00999

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00999 (BR1240F)
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
AJCC IIA / Grade:3
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Publications citing this model

Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient

Sex
Female
Age (at time of tissue collection)
45
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / No

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample BR1240F002P0 from passage P0 has a TMB score of 2.43
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:BR1240F002P0 from passage P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0, P1, P2 pathology consistent with high grade breast carcinoma. P3 pathology and staining consistent with triple negative breast carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00999 stained for H&E.

P0 tumor F002 for PDX model TM00999 stained for H&E.

P0 tumor F002 for PDX model TM00999 stained for vimentin. Staining was positive.

P1 tumor F002 P0022 for PDX model TM00999 stained for AR. Staining was negative.

P1 tumor F002 P0022 for PDX model TM00999 stained for ER. Staining was negative.

P1 tumor F002 P0022 for PDX model TM00999 stained for ERBB2 (HER2). Staining was negative.

P1 tumor F002 P0022 for PDX model TM00999 stained for PR. Staining was negative.

P2 tumor F002 ID499 for PDX model TM00999 stained for H&E.

P2 tumor F002 ID499 for PDX model TM00999 stained for AE1AE3. Staining was positive.

P2 tumor F002 ID499 for PDX model TM00999 stained for CD45. Staining was negative.

P3 tumor F002 ID16 for PDX model TM00999 stained for H&E.

P3 tumor F002 ID16 for PDX model TM00999 stained for AE1/AE3. Staining was positive.

P3 tumor F002 ID16 for PDX model TM00999 stained for CD45. Staining was negative.

P3 tumor F002 ID16 for PDX model TM00999 stained for Ki67. Staining was positive.

P3 tumor F002 ID16 for PDX model TM00999 stained for AR. Staining was negative.

P3 tumor F002 ID16 for PDX model TM00999 stained for ER. Staining was negative.

P3 tumor F002 ID16 for PDX model TM00999 stained for ERBB2 (HER2). Staining was negative.

P3 tumor F002 ID16 for PDX model TM00999 stained for PR. Staining was negative.

Dosing Studies

Circos Plots

no data