PDX Model DetailsTM01029

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM01029 (BL0215F)
Initial Diagnosis
Bladder urothelial papillary carcinoma
Final Diagnosis
Invasive bladder transitional cell carcinoma
Stage/Grade
Not Specified / Grade:high
Primary Site
Bladder
Sample Site
Bladder
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Male
Age (at time of tissue collection)
77
Race/Ethnicity
White / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample BL0215F124P0 from passage P0 has a TMB score of 10.5
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:BL0215F124P0 from passage P0     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0 pathology consistent with transitional cell carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM01029. High grade urothelial carcinoma invading bladder wall.
P0 tumor #124 for PDX model TM01029. Sheets of high grade urothelial carcinoma cells.

P1 tumor F124 for PDX model TM01029 stained for AE1AE3. Staining was positive.
P1 tumor F124 for PDX model TM01029 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots

 no data