PDX Model DetailsTM01039

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM01039 (KD2232F)
Initial Diagnosis
Renal cell carcinoma
Final Diagnosis
Clear cell renal cell carcinoma
Stage/Grade
Not Specified / Grade:1
Primary Site
Kidney
Sample Site
Kidney
Tumor Type
Primary Malignancy

Publications citing this model

 Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient
Sex
Female
Age (at time of tissue collection)
61
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

no CNV data

CNV Plots

no CNV plots

Tumor Mutation Burden
Sample KD2232F106P0000P1019P2 from passage P2 has a TMB score of 8.08
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:KD2232F106P0000P1019P2 from passage P2     Score:MSI-H

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0, P1 pathology consistent with renal cell carcinoma, clear cell type.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F106 for PDX model TM01039 stained for H&E.
P1 tumor F106 P0022 for PDX model TM01039 stained for H&E.

P1 tumor F106 P0022 for PDX model TM01039 stained for AE1AE3. Staining was positive.
P1 tumor F106 P0022 for PDX model TM01039 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots

 no data