PDX Model DetailsTM01044

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PDX Model Summary
Model Details	Model ID (Previous ID) TM01044 (LY2238AF) Initial Diagnosis Adenocarcinoma Final Diagnosis Adenocarcinoma Stage/Grade AJCC IV / Primary Site Gallbladder Sample Site Liver Tumor Type Metastatic
Related Models	PDX models TM01044 and TM01045 originated from the same patient.
Patient	Sex Female Age (at time of tissue collection) 75 Race/Ethnicity White / Hispanic Treatment Naïve? Yes Current Smoker/Former Smoker Unknown / Unknown
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site no data

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: RNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample LY2238A16P01P1 from passage P1 has a TMB score of 5.66 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:LY2238A16P01P1 from passage P1 Score:MSI-S
Gene Fusion	no data

Model Characterization

Histology

Summary:
P0, P1 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM01044 stained for H&E.	P0 tumor F018 ID179 for PDX model TM01044 stained for H&E.
P1 tumor F018 ID179 for PDX model TM01044 stained for H&E.

Dosing Studies

no data

Circos Plots

no data