PDX Model DetailsTM01087

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM01087 (TM01087F)
Initial Diagnosis
Neuroblastoma
Final Diagnosis
Neuroblastoma
Stage/Grade
AJCC IV / Grade:3
Primary Site
Adrenal gland
Sample Site
Adrenal gland
Tumor Type
Metastatic

Publications citing this model

Malcolm, J; et al. Factors that influence response classifications in chemotherapy treated patient-derived xenografts (PDX). PeerJ. 2019 Mar 28;7:e6586.  10.7717/peerj.6586

Patient

Sex
Male
Age (at time of tissue collection)
4
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / No

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample TM01087F108P0104P1 from passage P1 has a TMB score of 3.23
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:TM01087F108P0104P1 from passage P1     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P2 pathology consistent with neuroblastoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

P2 tumor F108 ID252 for PDX model TM01087 stained for H&E.

P2 tumor F108 ID252 for PDX model TM01087 stained for AE1AE3. Staining was negative.

P2 tumor F108 ID252 for PDX model TM01087 stained for KI67. Staining was positive.

P2 tumor F108 ID252 for PDX model TM01087 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots

no data