PDX Model DetailsTM01141

Request information on the availability of this model.

PDX Model Summary

Model Details
Model ID (Previous ID)
TM01141 (TM01141F)
Initial Diagnosis
Squamous cell carcinoma
Final Diagnosis
Head and neck squamous cell carcinoma
Stage/Grade
Not Specified /
Primary Site
Head
Sample Site
Head
Tumor Type
Not Specified

Patient
Sex
Female
Age (at time of tissue collection)
56
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
Unknown
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Not Specified
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample TM01141F170P0000P1013P2 from passage P2 has a TMB score of 6.46
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:TM01141F170P0000P1013P2 from passage P2     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor ID170 for PDX model TM01141 stained for H&E.
P0 tumor ID170 for PDX model TM01141 stained for AE1/AE3. Staining was positive.

P0 tumor ID170 for PDX model TM01141 stained for KI67. Staining was positive.
P0 tumor ID170 for PDX model TM01141 stained for CD45. Staining was negative.

Dosing Studies

 no data

Circos Plots

 no data