PDX Model DetailsTM01165

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM01165 (TM01165F)
Initial Diagnosis
Alveolar rhabdomyosarcoma
Final Diagnosis
Alveolar rhabdomyosarcoma
Stage/Grade
AJCC III / Grade:3
Primary Site
Soft tissue
Sample Site
Muscle
Tumor Type
Primary Malignancy

Patient
Sex
Female
Age (at time of tissue collection)
2
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample TM01165F276P0160P1 from passage P1 has a TMB score of 3.23
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:TM01165F276P0160P1 from passage P1     Score:MSI-S

Gene Fusion

 no data

Model Characterization

Histology

 Summary:
P0, P1 and P3 pathology consistent with rhabdomyosarcoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

P0 tumor F276 for PDX model TM01165 stained for H&E.
P1 tumor F276 ID064 for PDX model TM01165 stained for H&E.

P1 tumor F276 ID064 for PDX model TM01165 stained for Ki67.
P3 tumor F276 ID007 for PDX model TM01165 stained for CD45. Staining was negative.

P3 tumor F276 ID007 for PDX model TM01165 stained for Desmin. Staining was positive.

Dosing Studies

 no data

Circos Plots

 no data